Wishing Well Hemp represents a caring hand in the CBD and hemp community. We understand the amazing potential and future of this medicine and think it should be available to everyone.

By working with and employing Colorado based farmers and staff we strive to ensure some of the highest quality and cleanest CBD based products available at a price that is affordable to everyone. We are currently focusing on wholesale of CBD products. In the future we will have retail products available right here on our site, without the crazy mark-ups you see in CBD today.

" Health is the greatest gift, contentment the greatest wealth, faithfulness the best relationship. "

— Buddha

Cannabidiol (CBD) is now federally legal, it is a primary component of cannabis. CBD is one of the most prominent cannabinoids found in cannabis. CBD will not cause you to feel high.  CBD does not bind to the CB1 and CB2 receptors like THC and instead causes therapeutic actions through indirect means.

CBD is an inhibitor of an enzyme known as FAAH. That enzyme is responsible for breaking down anandamide which is a naturally occurring endocannabinoid. By inhibiting this enzyme CBD creates more available anandamide by preventing it’s degradation.  Some benefits of having more available anandamide for the CB1 receptor include:

Lowering depression, anxiety, fear, and paranoia
Increasing myelin formation
Lowering inflammation
Increasing BDNF levels and PPARy expression
Reducing GPR55 signaling and prolactin

CBD is also an allosteric modulator; allosteric modulators change the shape of specific receptors to alter their ability to interact with neurotransmitters. CBD is a positive allosteric modulator of the mu and delta opioid receptors, which means it enhances the ability of those receptors to receive endogenous enkephalins which can have a number of positive effects.

High doses of CBD activate the 5-ht1A receptor. This receptor helps regulate anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting. CBDA shows the highest affinity for this receptor. [Source]

CBD will also antagonize GPR55 receptors, which are widely distributed in the brain and help control your blood pressure and bone density. Activated GPR55 promotes cancer cell poliferation. [Source]

Additionally, CBD will activate TRPV1 receptors which are involved in regulating pain, body temperature, and inflammation. Anandamines also target this receptor. [Source]

Finally, CBD will activate PPAR-gamma receptors located on the cell’s nuclei and play a role in your lipid uptake, insulin sensitivity, dopamine release, and the degradation of beta-amyloid plague. This effect can help explain the use of CBD in varied cases of Alzheimer’s disease, schizophrenia, and diabetes. Thus in conclusion, we see a wide variety of medical uses in which CBD  has large efficacy.  CBD does not remain limited to these uses as we continue to discover further uses of this potent substance with federal legalization allowing wide-spread research.

" Fear is a narcotic, however truth is the most powerful drug. "

— Tim Dugan, Executive Officer

RSS Project CBD

  • CBD as a Steroid Sparing Treatment April 7, 2020
    Could cannabidiol be a breakthrough therapy to replace or lessen the use of steroids?
    sara
  • Cannabis, CBD & COVID-19 March 26, 2020
    What science says about CBD as an anti-viral agent. And, how prohibition is making a bad situation worse.
    sara
  • Women Pioneers in Cannabinoid Science March 26, 2020
    During a time of great crisis, we are reminded of the importance of medical science and the expert researchers who have dedicated their lives to advancing public health. In that context, we want to acknowledge Women’s History Month and celebrate the accomplishments of ten women who have made significant contributions to the advancement of cannabinoid […]
    sara
  • Synthetic Cannabinoids: Dangerous for Diabetics? March 16, 2020
    While smoking cannabis appears to be helpful for diabetics managing weight and insulin levels, synthetic cannabinoids could be dangerous. Spanish researchers recently documented a case where a diabetic man expressed dangerously high blood sugar levels after smoking an herbal blend treated with unknown synthetic cannabinoids.
    adrian
  • Did CBD Kill This Woman? March 16, 2020
    It can’t be emphasized enough that patients must be honest with their doctors about their cannabis use, particularly if CBD is involved, given its modulating effects on various CYP enzymes.
    tiffany
  • New Study: Cannabis Is Effective for Fibromyalgia March 10, 2020
    Fibromyalgia is an intractable condition defined by chronic, widespread pain and debilitation. But a recent study published in Clinical and Experimental Rheumatology demonstrated that cannabis can be used effectively to remedy these problems, at least by some patients.
    sara
  • New Developments in Cannabis Medicine with Bonni Goldstein, MD March 9, 2020
    Transcript
    Anonymous

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