Wishing Well Hemp represents a caring hand in the CBD and hemp community. We understand the amazing potential and future of this medicine and think it should be available to everyone.
By working with and employing Colorado based farmers and staff we strive to ensure some of the highest quality and cleanest CBD based products available at a price that is affordable to everyone. We are currently focusing on wholesale of CBD products. In the future we will have retail products available right here on our site, without the crazy mark-ups you see in CBD today.
" Health is the greatest gift, contentment the greatest wealth, faithfulness the best relationship. "
— Buddha
Cannabidiol (CBD) is now federally legal, it is a primary component of cannabis. CBD is one of the most prominent cannabinoids found in cannabis. CBD will not cause you to feel high. CBD does not bind to the CB1 and CB2 receptors like THC and instead causes therapeutic actions through indirect means.
CBD is an inhibitor of an enzyme known as FAAH. That enzyme is responsible for breaking down anandamide which is a naturally occurring endocannabinoid. By inhibiting this enzyme CBD creates more available anandamide by preventing it’s degradation. Some benefits of having more available anandamide for the CB1 receptor include:
63%
In 2015, 63.1% of all drug overdose related deaths in the U.S. came from opioid related deaths. Research of CBD has shown a significant decline in daily opioid use in a test study of patients on medicare over 65. Research suggests that there are multiple mechanisms of action that may result in the substitution of cannabis for opioids. In a study of cannabinoid-opioid interactions, Abrams et al. (2011) note that cannabinoids and opioids share many similar therapeutic and pharmacodynamics properties, including analgesic effects; the potential to induce hypothermia, sedation, and hypotension; as well as inhibition of intestinal motility and locomotor activity [Source], adding that“Synergy in analgesic effects between opioids and cannabinoids has been demonstrated in animal models. The antinociceptive effects of morphine are mediated predominantly by mu opioid receptors but may be enhanced by delta-9-tetrahydrocannabinol (THC) activation of kappa and delta opiate receptors [1]. It has further been suggested that the cannabinoid–opioid interaction may occur at the level of their signal transduction mechanisms [2, 3]. Receptors for both classes of drugs are coupled to similar intracellular signaling mechanisms that lead to a decrease in cyclic adenosine monophosphate production via G protein activation [3–4]. There is also some evidence that cannabinoids increase the synthesis and/or release of endogenous opioids.”
CBD is also an allosteric modulator; allosteric modulators change the shape of specific receptors to alter their ability to interact with neurotransmitters. CBD is a positive allosteric modulator of the mu and delta opioid receptors, which means it enhances the ability of those receptors to receive endogenous enkephalins which can have a number of positive effects.
High doses of CBD activate the 5-ht1A receptor. This receptor helps regulate anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting. CBDA shows the highest affinity for this receptor. [Source]
CBD will also antagonize GPR55 receptors, which are widely distributed in the brain and help control your blood pressure and bone density. Activated GPR55 promotes cancer cell poliferation. [Source]
Additionally, CBD will activate TRPV1 receptors which are involved in regulating pain, body temperature, and inflammation. Anandamines also target this receptor. [Source]
Finally, CBD will activate PPAR-gamma receptors located on the cell’s nuclei and play a role in your lipid uptake, insulin sensitivity, dopamine release, and the degradation of beta-amyloid plague. This effect can help explain the use of CBD in varied cases of Alzheimer’s disease, schizophrenia, and diabetes. Thus in conclusion, we see a wide variety of medical uses in which CBD has large efficacy. CBD does not remain limited to these uses as we continue to discover further uses of this potent substance with federal legalization allowing wide-spread research.
" Fear is a narcotic, however truth is the most powerful drug. "
— Tim Dugan, Executive Officer
Project CBD
- Cannabis Botany and Breeding with Ryan LeeExpert cannabis botanist and breeder Ryan Lee talks to Project CBD about the history of breeding cannabis, the discovery of CBD, and how to interpret lab data.
- Spirit MoleculesHumans love finding ways to alter our consciousness, and psychedelic plants have long provided a way to do so. Why do these plants produce intoxicating compounds?
- The Power Couple of Cannabis Therapeutics
- CBD & Booze: Bingeing on ResearchWhat’s the right dose of CBD when you take it orally? It’s a simple question with a muddled answer. Recently, researchers explored how eating impacts absorption of CBD. They also examined alcohol’s impact - for unclear reasons.
- Tough Times After High Hopes for Hemp HarvestA year has passed since President Trump signed the 2018 Farm Bill, which legalized the cultivation of industrial and CBD-rich hemp. So, how’d it go?
- Hit & RunA flawed study by Harvard scientists claims that marijuana smokers get into more car accidents even when they’re not high. Stoned driving should be considered when assessing the public health impact of cannabis, but not disproportionate to the established harm.
- Cannabis & Binge DrinkingWhat impact does cannabis legalization have on other substance use by college students? A recent study out of Oregon State University (OSU) aimed to find out.
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