Wishing Well Hemp represents a caring hand in the CBD and hemp community. We understand the amazing potential and future of this medicine and think it should be available to everyone.

By working with and employing Colorado based farmers and staff we strive to ensure some of the highest quality and cleanest CBD based products available at a price that is affordable to everyone. We are currently focusing on wholesale of CBD products. In the future we will have retail products available right here on our site, without the crazy mark-ups you see in CBD today.

" Health is the greatest gift, contentment the greatest wealth, faithfulness the best relationship. "

— Buddha

Cannabidiol (CBD) is now federally legal, it is a primary component of cannabis. CBD is one of the most prominent cannabinoids found in cannabis. CBD will not cause you to feel high.  CBD does not bind to the CB1 and CB2 receptors like THC and instead causes therapeutic actions through indirect means.

CBD is an inhibitor of an enzyme known as FAAH. That enzyme is responsible for breaking down anandamide which is a naturally occurring endocannabinoid. By inhibiting this enzyme CBD creates more available anandamide by preventing it’s degradation.  Some benefits of having more available anandamide for the CB1 receptor include:

Lowering depression, anxiety, fear, and paranoia
Increasing myelin formation
Lowering inflammation
Increasing BDNF levels and PPARy expression
Reducing GPR55 signaling and prolactin

CBD is also an allosteric modulator; allosteric modulators change the shape of specific receptors to alter their ability to interact with neurotransmitters. CBD is a positive allosteric modulator of the mu and delta opioid receptors, which means it enhances the ability of those receptors to receive endogenous enkephalins which can have a number of positive effects.

High doses of CBD activate the 5-ht1A receptor. This receptor helps regulate anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting. CBDA shows the highest affinity for this receptor. [Source]

CBD will also antagonize GPR55 receptors, which are widely distributed in the brain and help control your blood pressure and bone density. Activated GPR55 promotes cancer cell poliferation. [Source]

Additionally, CBD will activate TRPV1 receptors which are involved in regulating pain, body temperature, and inflammation. Anandamines also target this receptor. [Source]

Finally, CBD will activate PPAR-gamma receptors located on the cell’s nuclei and play a role in your lipid uptake, insulin sensitivity, dopamine release, and the degradation of beta-amyloid plague. This effect can help explain the use of CBD in varied cases of Alzheimer’s disease, schizophrenia, and diabetes. Thus in conclusion, we see a wide variety of medical uses in which CBD  has large efficacy.  CBD does not remain limited to these uses as we continue to discover further uses of this potent substance with federal legalization allowing wide-spread research.

" Fear is a narcotic, however truth is the most powerful drug. "

— Tim Dugan, Executive Officer

RSS Project CBD

  • Is CBD Toxic to the Liver? July 11, 2019
    The huge popularity of cannabidiol (CBD), a non-intoxicating component of cannabis, has helped to destigmatize the plant and restore its reputation as an important medicinal herb.
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  • Do Cannabis Suppositories Work? July 4, 2019
    The back door is making a comeback - medically speaking. Cannabis oil suppositories have grown in popularity, but how and to what extent they actually work remains somewhat of a mystery.
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  • When CBD Isn't Enough to Treat Epilepsy June 27, 2019
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  • What Causes Seizures? June 26, 2019
    A variety of different things may happen as a result of a seizure, depending upon the region of the brain that is affected. There may be sudden changes in sensory perception, such as visual disturbances or the smell of an unusual odor. There may be rapid and inexplicable emotional or cognitive changes. There are often […]
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  • CBD for Brain-Damaged Babies? June 20, 2019
    Giving medical cannabis to infants is a difficult taboo to shift, but new research is paving the way. The launch of a clinical trial examining the use of CBD in newborns suffering from hypoxic ischemic encephalopathy (brain damage caused by lack of oxygen) means new hope for the million plus babies born each year with […]
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  • 5 CBD Secrets June 11, 2019
    Cannabidiol and CBD oil seem to be everywhere these days, despite the confusing legal status of this prolific compound. But how much do we actually know about CBD?
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  • Tell the FDA What's on Your Mind June 5, 2019
    The FDA is asking for input on how to regulate CBD and cannabis. Project CBD gave oral comments at last week’s public hearing, and we plan on submitting written comments and supporting documents to their public docket. You should, too.
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