Wishing Well Hemp represents a caring hand in the CBD and hemp community. We understand the amazing potential and future of this medicine and think it should be available to everyone.

By working with and employing Colorado based farmers and staff we strive to ensure some of the highest quality and cleanest CBD based products available at a price that is affordable to everyone. We are currently focusing on wholesale of CBD products. In the future we will have retail products available right here on our site, without the crazy mark-ups you see in CBD today.

" Health is the greatest gift, contentment the greatest wealth, faithfulness the best relationship. "

— Buddha

Cannabidiol (CBD) is now federally legal, it is a primary component of cannabis. CBD is one of the most prominent cannabinoids found in cannabis. CBD will not cause you to feel high.  CBD does not bind to the CB1 and CB2 receptors like THC and instead causes therapeutic actions through indirect means.

CBD is an inhibitor of an enzyme known as FAAH. That enzyme is responsible for breaking down anandamide which is a naturally occurring endocannabinoid. By inhibiting this enzyme CBD creates more available anandamide by preventing it’s degradation.  Some benefits of having more available anandamide for the CB1 receptor include:

Lowering depression, anxiety, fear, and paranoia
Increasing myelin formation
Lowering inflammation
Increasing BDNF levels and PPARy expression
Reducing GPR55 signaling and prolactin

CBD is also an allosteric modulator; allosteric modulators change the shape of specific receptors to alter their ability to interact with neurotransmitters. CBD is a positive allosteric modulator of the mu and delta opioid receptors, which means it enhances the ability of those receptors to receive endogenous enkephalins which can have a number of positive effects.

High doses of CBD activate the 5-ht1A receptor. This receptor helps regulate anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting. CBDA shows the highest affinity for this receptor. [Source]

CBD will also antagonize GPR55 receptors, which are widely distributed in the brain and help control your blood pressure and bone density. Activated GPR55 promotes cancer cell poliferation. [Source]

Additionally, CBD will activate TRPV1 receptors which are involved in regulating pain, body temperature, and inflammation. Anandamines also target this receptor. [Source]

Finally, CBD will activate PPAR-gamma receptors located on the cell’s nuclei and play a role in your lipid uptake, insulin sensitivity, dopamine release, and the degradation of beta-amyloid plague. This effect can help explain the use of CBD in varied cases of Alzheimer’s disease, schizophrenia, and diabetes. Thus in conclusion, we see a wide variety of medical uses in which CBD  has large efficacy.  CBD does not remain limited to these uses as we continue to discover further uses of this potent substance with federal legalization allowing wide-spread research.

" Fear is a narcotic, however truth is the most powerful drug. "

— Tim Dugan, Executive Officer

RSS Project CBD

  • CBD Survey Results: Cultivating Wellness September 17, 2019
    Who is using CBD and why? Despite the huge public interest in CBD products, and an endless stream of media stoking that fire, there have been limited efforts to figure out exactly how and why people are using this darling compound of the cannabis world.
    zoe
  • The CBD Silly Season September 5, 2019
    With current market predictions estimating CBD sales at over $20 billion in the U.S. alone, it’s no wonder other business sectors want to get in on the act. But it’s the addition of CBD to textiles and clothing that has got industry insiders scratching their heads. How did CBD suddenly get added into everything?
    zoe
  • Cannabis and Incontinence August 27, 2019
    Because bladder control falls mostly to the central nervous system, it’s no surprise that cannabis may present novel and effective treatment options. We know that cannabinoid receptors are profusely expressed in both the central nervous system and peripheral nervous system. And we also know that these receptors are activated by endogenous compounds as well as […]
    daphnechurch
  • Can CBD Help Your Complexion? August 21, 2019
    Is there anything substantive behind all the hype? Can CBD really protect, heal and restore the skin? What, if anything, does the science say about all this?
    daphnechurch
  • How to Make a CBD Topical for Healthy Skin August 21, 2019
    Given CBD’s potent antioxidant, anti-cancer, anti-bacterial, and anti-inflammatory properties, it’s a perfect ingredient to add to a natural skin oil preparation. Learn how to make yours.
    daphnechurch
  • CBD for Autism: The Therapeutic Promise August 21, 2019
    From Wholistic Research & Education Foundation.
    martin
  • Comments to the Food & Drug Administration on CBD and Cannabis August 19, 2019
    Read Project CBD’s special report commenting on cannabis science to the FDA.
    admin

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