Wishing Well Hemp represents a caring hand in the CBD and hemp community. We understand the amazing potential and future of this medicine and think it should be available to everyone.

By working with and employing Colorado based farmers and staff we strive to ensure some of the highest quality and cleanest CBD based products available at a price that is affordable to everyone. We are currently focusing on wholesale of CBD products. In the future we will have retail products available right here on our site, without the crazy mark-ups you see in CBD today.

" Health is the greatest gift, contentment the greatest wealth, faithfulness the best relationship. "

— Buddha

Cannabidiol (CBD) is now federally legal, it is a primary component of cannabis. CBD is one of the most prominent cannabinoids found in cannabis. CBD will not cause you to feel high.  CBD does not bind to the CB1 and CB2 receptors like THC and instead causes therapeutic actions through indirect means.

CBD is an inhibitor of an enzyme known as FAAH. That enzyme is responsible for breaking down anandamide which is a naturally occurring endocannabinoid. By inhibiting this enzyme CBD creates more available anandamide by preventing it’s degradation.  Some benefits of having more available anandamide for the CB1 receptor include:

Lowering depression, anxiety, fear, and paranoia
Increasing myelin formation
Lowering inflammation
Increasing BDNF levels and PPARy expression
Reducing GPR55 signaling and prolactin

CBD is also an allosteric modulator; allosteric modulators change the shape of specific receptors to alter their ability to interact with neurotransmitters. CBD is a positive allosteric modulator of the mu and delta opioid receptors, which means it enhances the ability of those receptors to receive endogenous enkephalins which can have a number of positive effects.

High doses of CBD activate the 5-ht1A receptor. This receptor helps regulate anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting. CBDA shows the highest affinity for this receptor. [Source]

CBD will also antagonize GPR55 receptors, which are widely distributed in the brain and help control your blood pressure and bone density. Activated GPR55 promotes cancer cell poliferation. [Source]

Additionally, CBD will activate TRPV1 receptors which are involved in regulating pain, body temperature, and inflammation. Anandamines also target this receptor. [Source]

Finally, CBD will activate PPAR-gamma receptors located on the cell’s nuclei and play a role in your lipid uptake, insulin sensitivity, dopamine release, and the degradation of beta-amyloid plague. This effect can help explain the use of CBD in varied cases of Alzheimer’s disease, schizophrenia, and diabetes. Thus in conclusion, we see a wide variety of medical uses in which CBD  has large efficacy.  CBD does not remain limited to these uses as we continue to discover further uses of this potent substance with federal legalization allowing wide-spread research.

" Fear is a narcotic, however truth is the most powerful drug. "

— Tim Dugan, Executive Officer

RSS Project CBD

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    Two compounds that target the endocannabinoid system are currently in development to treat scleroderma – and they’re already in clinical trials. Pharmaceutical researchers have their sights set on developing a drug that bypasses CB1 while boosting CB2. Referred to as a “selective CB2 agonist,” such a compound would appear to have potential as a treatment […]
  • Better Than Cannabis?
    In recent years, cannabis has been at the center of one of the most important developments in modern science - significantly advancing our understanding of health and disease.
  • What Should We Do About Vaping?
    Rather than banning an entire product category – be it vapes or edibles – state health officials should implement a rigorous regulatory program that prioritizes public health and raises the safety standards for all edibles and food supplements.
  • Is CBD an Endocannabinoid Reuptake Inhibitor?
    Project CBD speaks with Matt Elmes, PhD, director of new product development at CannaCraft, about his post-doctoral research on CBD, fatty acid transport molecules, and the endocannabinoid system.
  • CBD Survey Results: Cultivating Wellness
    Who is using CBD and why? Despite the huge public interest in CBD products, and an endless stream of media stoking that fire, there have been limited efforts to figure out exactly how and why people are using this darling compound of the cannabis world.

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