Wishing Well Hemp represents a caring hand in the CBD and hemp community. We understand the amazing potential and future of this medicine and think it should be available to everyone.

By working with and employing Colorado based farmers and staff we strive to ensure some of the highest quality and cleanest CBD based products available at a price that is affordable to everyone. We are currently focusing on wholesale of CBD products. In the future we will have retail products available right here on our site, without the crazy mark-ups you see in CBD today.

" Health is the greatest gift, contentment the greatest wealth, faithfulness the best relationship. "

— Buddha

Cannabidiol (CBD) is now federally legal, it is a primary component of cannabis. CBD is one of the most prominent cannabinoids found in cannabis. CBD will not cause you to feel high.  CBD does not bind to the CB1 and CB2 receptors like THC and instead causes therapeutic actions through indirect means.

CBD is an inhibitor of an enzyme known as FAAH. That enzyme is responsible for breaking down anandamide which is a naturally occurring endocannabinoid. By inhibiting this enzyme CBD creates more available anandamide by preventing it’s degradation.  Some benefits of having more available anandamide for the CB1 receptor include:

Lowering depression, anxiety, fear, and paranoia
Increasing myelin formation
Lowering inflammation
Increasing BDNF levels and PPARy expression
Reducing GPR55 signaling and prolactin

CBD is also an allosteric modulator; allosteric modulators change the shape of specific receptors to alter their ability to interact with neurotransmitters. CBD is a positive allosteric modulator of the mu and delta opioid receptors, which means it enhances the ability of those receptors to receive endogenous enkephalins which can have a number of positive effects.

High doses of CBD activate the 5-ht1A receptor. This receptor helps regulate anxiety, addiction, appetite, sleep, pain perception, nausea, and vomiting. CBDA shows the highest affinity for this receptor. [Source]

CBD will also antagonize GPR55 receptors, which are widely distributed in the brain and help control your blood pressure and bone density. Activated GPR55 promotes cancer cell poliferation. [Source]

Additionally, CBD will activate TRPV1 receptors which are involved in regulating pain, body temperature, and inflammation. Anandamines also target this receptor. [Source]

Finally, CBD will activate PPAR-gamma receptors located on the cell’s nuclei and play a role in your lipid uptake, insulin sensitivity, dopamine release, and the degradation of beta-amyloid plague. This effect can help explain the use of CBD in varied cases of Alzheimer’s disease, schizophrenia, and diabetes. Thus in conclusion, we see a wide variety of medical uses in which CBD  has large efficacy.  CBD does not remain limited to these uses as we continue to discover further uses of this potent substance with federal legalization allowing wide-spread research.

" Fear is a narcotic, however truth is the most powerful drug. "

— Tim Dugan, Executive Officer

RSS Project CBD

  • Comments to the Food & Drug Administration on CBD and Cannabis August 19, 2019
    Read Project CBD’s special report commenting on cannabis science to the FDA.
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  • Neuro-oncology, Functional Medicine, and Medical Cannabis in Brazil August 14, 2019
    In this edition of Cannabis Conversations, Project CBD speaks with Dr. Paula Dall’Stella, a leading cannabis clinician in San Paolo, Brazil.
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  • CBD Science Update August 6, 2019
    The 29th annual International Cannabinoid Research Society (ICRS) symposium, which convened last month in Bethesda, Maryland, featured new developments in CBD science that have far-reaching implications for many areas of medicine. Just over 500 participants from around the world attended the four-day conference, which included 65 oral presentations and nearly 200 posters covering a wide […]
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  • How Cannabis is Transforming Oklahoma August 1, 2019
    In 1997, Will Foster, then 38, was sentenced to 93 years in an Oklahoma state prison for growing a small cannabis garden in a locked bomb shelter under his home in Tulsa.
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  • Cannabis for Contact Sports July 25, 2019
    Rugby is a physically demanding sport that requires both mental focus and a high tolerance for pain. It’s a full-contact tackle sport with no pads and no helmets, and the game flows freely with few stoppages – meaning continuous sprinting and collisions throughout the full 80 minutes of the match.
    zoe
  • Petition: Remove the Cannabis Ban for Athletes July 25, 2019
    Athletes for CARE is a nonprofit created by current and former professional athletes dedicated to using their influence for social change. They aim to protect the health and wellbeing of current and former athletes around the world.
    zoe
  • Now This: Martin Lee and the CBD Revolution July 18, 2019
    This activist is the reason you know about CBD. Now he’s telling the history behind the cannabinoid.
    zoe

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